(S,R,S)-AHPC-PEG2-NH2 hydrochloride ( VH032-PEG2-NH2 hydrochloride | VHL Ligand-Linker Conjugates 3 hydrochloride | E3 ligase Ligand-Linker Conjugates 6 )

产品货号. M26952 CAS No. 2097973-72-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

(S,R,S)-AHPC-PEG2-NH2 hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

(S,R,S)-AHPC-PEG2-NH2 盐酸盐 (VH032-PEG2-NH2 盐酸盐) 是一种合成的 E3 连接酶配体-接头缀合物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 2 单元用于合成 PROTAC 的 PEG 连接体。
产品描述

(S,R,S)-AHPC-PEG2-NH2 hydrochloride (VH032-PEG2-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.
体外实验

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
体内实验

——
同义词

VH032-PEG2-NH2 hydrochloride | VHL Ligand-Linker Conjugates 3 hydrochloride | E3 ligase Ligand-Linker Conjugates 6
通路

Others
靶点

Other Targets
受体

5-HT7
研究领域

——
适应症

——

CAS Number

2097973-72-1
分子量

612.18
分子式

C28H42ClN5O6S
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 150 mg/mL (245.03 mM)
SMILES

O=C([C@H]1N(C([C@@H](NC(COCCOCCN)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2.[H]Cl
化学全称

——

1.Guscott MR, et al. The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor. Neuropharmacology. 2003;44(8):1031-1037.

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